資源描述:
《體部伽瑪?shù)堵?lián)合介入化療栓塞治療中晚期肝癌的meta分析-論文.pdf》由會員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、·430·西部醫(yī)學(xué)2014年4月第26卷第4期MedJWestChina,April2014,Vo1.26,No.4體部伽瑪?shù)堵?lián)合介入化療栓塞治療中晚期肝癌的meta分析*黨亞正,王國棟,陸婉玲,李迎春,衛(wèi)偉(解放軍第323醫(yī)院綜合內(nèi)科,陜西西安710054)【摘要】目的系統(tǒng)評價體部伽瑪?shù)?StereotacticBodyRadiationTherapy,SBRT)聯(lián)合介入化療栓塞術(shù)(transcath—eterarterialchemoembolization,TACE)治療中晚期原發(fā)性肝癌的療效及安全性,為臨床決策提供循證醫(yī)學(xué)依據(jù)。方法計算機(jī)檢索CoehraneLibrary、PubM
2、ed、CBM、CNKI、VIP、WanFangData等數(shù)據(jù)庫,收集所有伽瑪?shù)堵?lián)合TACE治療中晚期肝癌比較單純TACE治療的隨機(jī)對照試驗(RCT),提取文獻(xiàn)資料和評價納入研究質(zhì)量,以軟件RevMan5.1進(jìn)行Meta分析。結(jié)果共納入11篇文獻(xiàn),共ll15例患者。Meta分析結(jié)果顯示:伽瑪?shù)堵?lián)合TACE組與單純TACE組相比,其1、2年生存率、總有效率的差異均有統(tǒng)計學(xué)意義(P0.05)。結(jié)論超級伽瑪?shù)堵?lián)合介入化療栓塞與單純TACE組相比,能明顯提高中晚期肝癌患者的近期療效和1年、2年生存率,聯(lián)合治療組副作用并未加重。聯(lián)合治療遠(yuǎn)期療效還有待開展更
3、多高質(zhì)量、大樣本的RCT實驗加以驗證?!娟P(guān)鍵詞】肝細(xì)胞癌;體部伽瑪?shù)?;介入化療栓塞術(shù);Meta分析【中圖分類號】R735.7【文獻(xiàn)標(biāo)志碼】Adoi:10.3969/j.issn.1672—3511.2014.04.009Meta-analysisofSBRTcombinedwithtaceforadvancedhepatoceilularcarcinomaDANGYa-zheng,WANGGuo-dong,LUWan-ling,etal(CancerCenter,323HospitalofChinesePeople'sLiberationArmy,Xi’all710054)[Abstrac
4、t】ObjectiveInordertoprovidephysicianswithsupportofevidence-basedmedcineinclinicalpractice,weassessedtheclinica1efficacyandsafetyofGamma-knifecombinedwithtranscatheterarterialchemoembolization(TACE)forintermediate-advanced-stagehepatocellularcarcinoma(HCC).MethodsAllofthereferences,publicationdatef
5、rom1989to2013,concerningsuchsubjectweresearchedindatabsesincludingCochraneLibrary,PubMed,EMbase,CBM。CNKI,VIP.QualityofreferenceswasevaluatedaccordingtoCochranceHandbook4.2.6,andmcta—analysiswereconduc—tedbyRevMan5.1software.ResultsElevenrandomizedcontrolledtrails(RCT)including1115patientswereenrol
6、ledinsuchmetaanalysis,resultsrevealedthatsurvivalratesofl,2and3yearincombinationgroupweremorehigherthanthatofinTACEgroup.ThesideeffectsintWOgroupshavenosignificantdifference.ConclusionTACEcombinedwithGammaknifecanimprove1ong—termsurvivalrateandshort—termcurativeeffectcomparingwithTACEgroup.whileit
7、slong—termcurativeeffectandsafetystillneedstobefurtherverifiedinmeta-analysiswithmore1argesampleandhighqualityRCTs.[Keywords]HepatocellularCarcinomaStereotactic;BodyRadiationTherapy;Transcatheterarterialchemoembo