慢性肝衰竭患者真菌感染的危險(xiǎn)因素分析-論文.pdf

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1、·4582·中華醫(yī)院感染學(xué)雜志2013年第23卷第18期ChinJNosocomiolVo1．23No．182013論著慢性肝衰竭患者真菌感染的危險(xiǎn)因素分析羅燕，熊晏，林炳亮(1．貴州省人民醫(yī)院感染科，貴州貴陽550002；2．廣州中山大學(xué)附屬第三醫(yī)院傳染科，廣東廣州510630)摘要：目的探討慢性肝衰竭患者真菌感染的相關(guān)危險(xiǎn)因素，為臨床防治提供依據(jù)。方法選取廣州中山大學(xué)附屬第三醫(yī)院2010年1月一2012年1月收治的6o例慢性肝衰竭合并真菌感染患者作為研究對(duì)象，設(shè)為感染組，將同期未發(fā)生真菌感染60例患者設(shè)為對(duì)照組，對(duì)兩組患者感染相關(guān)因素進(jìn)行對(duì)比分析

2、。結(jié)果感染組病死率10．0，明顯高于對(duì)照組的5．0，差異有統(tǒng)計(jì)學(xué)意義(P

3、；危險(xiǎn)因素中圖分類號(hào)：R379文獻(xiàn)標(biāo)識(shí)碼：A文章編號(hào)：1005—4529(2013)18-4582—03RiskfactorsforfungalinfectionsinpatientswithchronicliverfailureLUOYan。XIONGYan。LINBing—liang(*GuizhouPeopleSHospital，Guiyang，Guizhou5500022，China)Abstract：OBa『ECTIVEToanalyzetherelatedriskfactorsforfungalinfectionsinpatientswi

4、thchronicliverfailureSOastoguidetheclinicaltreatment．METHODSAtotalof60casesofchronicliverfailurepatientscomplicatedwithfungalinfections，whoweretreatedinthehospitalfromJan2010tOJan2010，wereenrolledinthestudyandassignedastheinfectiongroup，and60casesofpatientswithoutinfectionswere

5、setasthecontrolgroup，thentherelatedfactorsfortheinfectionswereanalyzedandcomparedbetweenthetwogroups．RESULTSThemortalityoftheinfectiongroupwas10．0，significantlyhigherthan5．0ofthecontrolgroup，thedifferencewassignificant(P<0．05)．Theincidenceofbacterialinfectionswas78．33％intheinfe

6、ctiongroup，18．33inthecontrolgroup；theutilizationrateofantibioticswas93．33intheinfectiongroup，46．67inthecontrolgroup；therewere55casesofpatientswhounderwenttheinvasiveoperationintheinfectiongroupand18casesinthecontrolgroup，thedifferencebetweenthetwogroupswassignificant(P<0．05)．Th

7、elogisticregressionanalysisshowedthatthespeciesofpathogenscausinginfectionduringhospitalstay，totalbilirubinindexofliverfunction，lengthofhospitalstay，cumulativetimeofuseofantibiotics，invasiveoperation，andtypesofantibioticsusedweretheinde—pendentriskfactorsforfungalinfectionsinth

8、epatientswithchronicliverfailure．CONCLUSIONItisnecessa