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1、·490·J0URNALOFBASICANDCLINICALONCOLOGYVo1．26No．6Dec．20l3全身熱療聯(lián)合導(dǎo)管化療栓塞對中晚期肝癌的療效觀察張建國，鄭國寶(解放軍150醫(yī)院腫瘤科，河南洛陽471031)[摘要]目的觀察全身熱療聯(lián)合導(dǎo)管化療栓塞治療中晚期肝癌的療效及安全性。方法128例中晚期肝癌患者分為單純介入栓塞化療組(A組)和介入栓塞化療聯(lián)合全身熱療組(B組)，其中A組64例給予5一氟尿嘧啶、表柔比星、絲裂霉素介入栓塞化療2周期，B組64例用同樣藥物介入栓塞化療，同時給予深度鎮(zhèn)靜下全身熱療，使全身溫度升至40～4
2、2℃，維持90min，2周期；觀察A組和B組患者的療效及毒副反應(yīng)。結(jié)果A組患者中，CR0例，PR29例，sD19例，PD16例，有效率為45．3％；B組患者中，CR0例，PR41例，SD18例，PD5例，有效率為64．1％；2組有效率比較差異有統(tǒng)計學(xué)意義(P<0．05)。m、IV度肝功能損害、。腎功能損害、骨髓抑制及胃腸道反應(yīng)發(fā)生率A組為25．3％、13．1％及18．5％；B組為23．9％、11．4％及20．1％，2組比較差異均無統(tǒng)計學(xué)意義(P>0．05)。結(jié)論全身熱療聯(lián)合導(dǎo)管化療栓塞治療中晚期肝癌安全有效。[關(guān)鍵詞]全身熱療；化療
3、栓塞；肝癌DOI：10．3969／j．issn．1673—5412．2013．06．010[中圖分類號]R735．7；R730．58[文獻(xiàn)標(biāo)識碼]A[文章編號]1673—5412(2013)06—0490—03EficacyofWholeBodyHyperthermiaCombinedwithTranscatheterHepaticArterialChemoembolizationforPatientswithAdvancedHepaticCarcinomaZhangJianguo，ZhengGuobao(DepartmentofO
4、ncology，the150thCentralHospitalofPLA，Luoyang471031，China)[Abstract]0bjectiveTodeterminetheshortereficacyandsecurityofwholebodyhypeahermiacombinedwithtranscatheterhepaticarterialchemoembolizationforthepatientswithadvancedhepaticcarcinoma．MethodsThe128patientswithadvance
5、dhepaticcarcinomaweredividedintotwogroups．The64patients(GroupA)receivedtranscatheterhepaticarterialchemoembolization．Theother64patients(GroupB)receivedwholebodyhype~hermiaandwithtranscatheterhepatica~efialchemoembolization．Wholebodyhyperthermiawasmaintainedat40-42℃for9
6、0minindeepcalmness．ResultsIntheGroupA，CRwasobservedin0patient，PRinthe29patients．SDinthe19patients，PDinthe16patients，andtheoverallresponseratewas45．3％；whileintheGroupB，thecorrespond—ingfigureswere0，41，18，5and64．1％，respectively．Thereweresignificantdifferencesintheoverall
7、responseratebetweenthetwogroups(P<0．05)．TheincidencerateofgrademandIVabnormalliverfunction．a(chǎn)bnormalkidneyfunction，bonemarrowsuppressionandgastrointestinalreactionwere25．3％，13．1％and18．5％intheGroupA：while23．9％，11．4％and20．1％intheGroupB．nosignificantdifierencewasfoundinthe
8、incidenceratesoftox—icitiesbetweenthetwogroups(P>0．05)．ConclusionWholebodyhyperthermiacombinedwithtranscatheterhe．pat
