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1、第51卷第12期山東大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)2013年l2月VO1.5lNO.12JOURNALOFSHANDONGUNIVERSITY(HEALTHSCIENCES)Dec.2013文章編號(hào):1671—7554(2013)12—0061—06DOI:10.6040/j.issn.1671-7554.0.2013.167門靜脈癌栓分型對(duì)肝癌手術(shù)遠(yuǎn)期預(yù)后的影響孟海鵬,牛衛(wèi)博,吳小鵬,郭森,劉毅,陳雨信(山東大學(xué)齊魯醫(yī)院肝膽外科,濟(jì)南250012)摘要:目的探討門靜脈癌栓(PVTT)的部位與程度對(duì)肝癌手術(shù)
2、療效的影響。方法回顧性分析山東大學(xué)齊魯醫(yī)院普外科2010年1月至2012年12月203例行肝部分切除伴或不伴門靜脈切開取栓術(shù)的原發(fā)性肝癌合并門靜脈癌栓患者的臨床資料,對(duì)其臨床特征、復(fù)發(fā)及生存情況進(jìn)行分析。結(jié)果203例患者的并發(fā)癥率和住院死亡率分別為30.0%和0.5%,中位隨訪期6.5個(gè)月。1年和3年生存率分剮為33.5%和12.8%,1年和3年元病生存率分別為10.8%和3.0%。合并VPI(PVTT局限于門靜脈二級(jí)分支以遠(yuǎn))、VP2(PVTT侵犯門靜脈二級(jí)分支)、VP3(PVTT侵犯門靜脈一
3、級(jí)分支)型PVTT患者的生存率顯著高于合并VP4(PVTT累及門靜脈主干或?qū)?cè)一級(jí)分支)型PvTr的患者。結(jié)論對(duì)于合并VP1、VP2、VP3型PVTT的肝癌患者,手術(shù)是合理的選擇。而對(duì)于PV1Tr累及門靜脈主干(VP4)的肝癌患者,手術(shù)仍有爭議,待進(jìn)一步研究。關(guān)鍵詞:肝細(xì)胞癌;門靜脈癌栓;門靜脈;外科治療中圖分類號(hào):R735.7文獻(xiàn)標(biāo)志碼:AEffectsoftypeofPVTTonlong—termoutcomesofsurgicaltreatmentforhepatocellularcarc
4、inomaMENGHai—peng,NIUWei-bo,WUXiao-peng,GUOSen,LIUYi,CHENYu—xin(Departmentofhepatobiliarysurgery,QiluHospitalofShandongUniversity,Jinan250012,China)Abstract:0bjectiveToevaluateeffectsoflocationandextentofPVTronlong—termoutcomesofsurgicaltreatmentforh
5、epatocellularcarcinoma(HCC).MethodsAretrospectivestudywascarriedoutonpatientswhounderwentpartialhepatectomywithorwithoutportalthrombectomyforHCCwithPvTTinQiluHospita1ofShandongUniversityfromJanuary2010toDecember2012.Thepatientsclinicalcharacteristics
6、,recurrenceandsurvivalwereanalyzed.ResultsAtotalof203patientswithHCCandportalveintumorthrombus(PV1Tr)whounderwentpartialhepatectomywerestudied.111ecomplicationrateandhospitalmortalityratewererespective30.0%and0.5%,andmedianfollow—upwas6.5months.The1.
7、and3-yearoverallsurvivalrateswere33.5%and12.8%,respectively.耵1e1一and3-yeardisease—freesurvivalrateswere10.8%and3.O%,respectively.PatientswithVP1,VP2andVP3showedsignificantlybeRersurvivalthanthosewithVP4.ConclusionLiverresectioniSiustifiedinselectedpa
8、tientswithVP1,VP2andVP3.However.surgicalresectionforPVTTinvolvingthemaintrunk(VP4)iSstillcontroversia1.Keywords:Hepatocellularcarcinoma;Portalveintumorthrombus;Po~alvein;Surgicaltreatment肝細(xì)胞癌(hepatocellularcarcinoma,HCC)是一而且合并PVTT的肝癌患者,手術(shù)切除范圍往往較種預(yù)后較差