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《丙酮酸鈉-羥乙基淀粉復(fù)蘇對(duì)50％總體表面積燙傷大鼠腸道微血管通透性及腸屏障功能的影響》由會(huì)員上傳分享，免費(fèi)在線(xiàn)閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、萬(wàn)方數(shù)據(jù)英文摘要EffectsofPyruvate-basedHydroxyethylStarchonIntestinalMicrovascnlarPermeabilityandIntestinalBarrierFunctionofBurnInjuryinRatsObjective：Colloidscombinedwithcrystalloidsareoftenusedmtreatmentofburns，sepsisandvarioushypovolemicshockinclinicalsettings．Theplasmaandalbuminasnatur
2、alcolloidsarepreferred。Duetothedifficultyofobtainingbloodproducts，hydroxyethylstarch(船S)andotherartificialcolloidshavebeencommonlyappliedasthealtemativesofplasmaproductsbecauseoftheirfastandpowerfulexpansioneffects．However,seriousadversereactionsinducedbytheinfusionofHESwerefounda
3、thomeandabroadinrecentyears，thuswidespreadcontroversyWasraisedbytheuseofliES【¨．Severalpreviousstudiesshowedthatsodiumpyruvatehadanti—acid，anti—inflammatoryandanti-oxidanteffects，anditcouldreversetheglucosemetabolicdisturbanceandacid-baseimbalancecausedbyvariourtypesofshockandprote
4、ctorganfunction【2J．ThepurposeofthisstudyfocusesthesodiumpyruvateasanovelcarriersolutioninHES(pyruvate—basesHES)oneffectsonthereductionofvascularleakageandtissueedemaandtheprotectionofintestinalmicrovascularpermeabilityandintestinalbarrierfunction，comparedwithsodiumchloride-HESanda
5、cetateRinger．HESthatareusuallyusedintheclinicalsetting，inratssubjectedwithseverebums．Method：1AnimalModel：l00maleSDrats，weighing2209一2709，wereadaptivefeedingforoneweekafterpurchase．Fasting12hours，butfreeaccesstowateruntil4hoursbeforesurgery,ratswereplacedinanopenedprefabricatedcont
6、ainerafterintraperitonealinjectionforanesthesiabypentobarbitalsodium(50medkg)andcuttingoffhairsintheneck，back,buttocksandabdomen．Theratswereemmercedinboilingwater(100。Cwaterbathinboilingwater)for15secondsonbackand8secondsonabdomentocausea50％totalbodysurface(TBSA)III4萬(wàn)方數(shù)據(jù)英文摘要degree
7、bums．Ratsintheshamcontrolgroupwereplacedinwarmwater(37。Cwaterbath)for15secondsonbackand8secondsonabdomen．Injuredratswerethenasepticallyinsertedwithacatheterintothejugularveinforfluidinfusion，fixedwithaspecificexperimentalvestafterbeingconnectedtotheinfusiondeviceandplacedinthecage
8、s．Theshaftassemblyonthevestensure
