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1、·18·解放軍護(hù)理雜志2005Jun;22(6)肝素尿激酶混合液在血液透析雙腔導(dǎo)管封管中的應(yīng)用夏娟,馬玉英,居建忻(嘉興學(xué)院附屬第一醫(yī)院腎病科,浙江嘉興314000)摘要:目的探討肝素尿激酶混合液在血透用雙腔導(dǎo)管封管中的應(yīng)用價(jià)值。方法20例頸內(nèi)靜脈永久留置雙腔導(dǎo)管進(jìn)行血液透析患者,根據(jù)導(dǎo)管動脈端和靜脈端封管液的不同選擇,隨機(jī)分成肝素尿激酶混合液組(A組)和肝素組(B組),觀察比較兩組導(dǎo)管的堵塞次數(shù)和靜態(tài)管路壓。結(jié)果A組導(dǎo)管堵塞12例次,溶栓后全部再通,靜態(tài)管路壓為(10.2±3.57)cmH2O;B
2、組導(dǎo)管堵塞33例次,溶栓后再通31例次,靜態(tài)管路壓為(7.4±5.28)cmH2O。兩組導(dǎo)管堵塞例次和靜態(tài)管路壓有非常顯著性差異。結(jié)論肝素尿激酶混合液可應(yīng)用于頸內(nèi)靜脈留置雙腔導(dǎo)管的封管。關(guān)鍵詞:肝素;尿激酶;血液透析;雙腔導(dǎo)管中圖分類號:R45915文獻(xiàn)標(biāo)識碼:A文章編號:1008-9993(2005)06-0018-02InvestigationonSealingtheDoubleChannelCatheterbyMixedFluidofHeparin2urokinaseinHe2modialys
3、isXIAJuan,MAYu2ying,JUJian2xin(DepartmentofNephrology,FirstAffiliatedHospital,JiaxingCollege,Jiaxing314000,China)Abstract:ObjectiveTodeterminethevalueofthemixedfluidofheparin2urokinaseonsealingthedoub2lechannelcatheterinhemodialysis.MethodsAccordingtot
4、hedifferentchoicesofsealingfluidinthearterialorvenousendofthedoublechannelcatheter,20patientswithpermanentindwellingofthedoublechannelcatheterintheinternaljugularveinwererandomlydistributedintogroupsAandB.GroupAre2ceivedthemixedfluidofheparin2urokinase
5、,whilegroupBreceivedheparin.BlockagetimesandstaticpipepressurebetweengroupAandBwerecompared.ResultsTherewere12episodesofcatheterob2structioningroupA,allofwhichbecamepatentafterthrombolysis.Themeanstaticpipepressurewas(1012±3.57)cmH2O.Therewere33episode
6、sofcatheterobstructioningroupB,31ofwhichbecamepatentafterthrombolysisandtwofailedtopass.Themeanstaticpipepressurewas(7.4±5.28)cmH2O.Thedifferencesinobstructionfrequencyandstaticpipepressurewerestatisticallysignificantbetweenthetwogroups(P<0.001).Conclu
7、sionThemixtedfluidofheparin2urokinasecanbeusedforsealingin2trajugularpermanentlyindwellingdoublechannelcatheter.Keywords:heparin;urokinase;hemodialysis;doublechannelcatheter4腎功能衰竭患者應(yīng)用中心靜脈留置雙腔導(dǎo)管進(jìn)10U/2ml,上海第一生化藥業(yè)有限公司生產(chǎn)。尿激4行血液透析日益普及,但導(dǎo)管堵塞是影響雙腔導(dǎo)管酶5×10U/支,廣
8、東天普生物化學(xué)制藥有限公司生使用時(shí)間的主要因素之一。因此,有必要對如何保4產(chǎn)。將2ml肝素液溶解5×10U尿激酶配制成肝持導(dǎo)管通暢進(jìn)行研究,而其中封管液的選擇和正確素尿激酶液。使用非常重要。本課題采用隨機(jī)對照的研究方法,1.3方法比較肝素尿激酶混合液和肝素在頸內(nèi)靜脈留置雙腔1.3.1分組方法透析前1d,局麻下應(yīng)用Seldinger導(dǎo)管封管中的效果。技術(shù)和撕脫型擴(kuò)張器將導(dǎo)管置入頸內(nèi)靜脈。隨機(jī)將1資料與方法同一導(dǎo)管的動脈端和靜脈端根據(jù)選用封管液的不同1.1研究對象選取20
