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《吉西他濱在大鼠腦膠質(zhì)瘤模型中的藥動學研究及冰片對其藥動學的影響》由會員上傳分享，免費在線閱讀，更多相關內(nèi)容在學術(shù)論文-天天文庫。
1、研究生個人簡介姓名：房紹英性別：女年齡：25英語：大學英語六級已修學分：33．5學習及工作經(jīng)歷：2005．09"-'2010．07，泰山醫(yī)學院藥學(臨床藥學)專業(yè)，獲醫(yī)學學士學位2010．09～2013．07，徐州醫(yī)學院藥理學專業(yè)，獲醫(yī)學碩士學位研究生期間科研成果及獲獎情況：2013年，JournalofChromatographyB，參與論文一篇，己發(fā)表目錄JIlflJlllflllflrlfUlWJIIIIJlJIIIIflll[JJIlll0Y2435249縮略詞表?????????????????????????????．1第一部分吉西他濱在大鼠腦膠質(zhì)瘤模型中的藥動學研究中文
2、摘要?????????????????????????????·2Abstract······························-·······························································4前言??????????????????????????????··7材料和方法???????????????????????????··91材料?????????????????????????????··92方法?????????????????????????????12結(jié)果??????????????????
3、????????????19討{侖??????????????????????????????29結(jié)論??????????????????????????????32第二部分冰片對吉西他濱在大鼠腦膠質(zhì)瘤模型中藥動學的影響中文摘要????????????????????????????··33Abstract····························································································34前言??????????????????????????????35材料和方法????????
4、???????????????????371材料?????????????????????????????372方法?????????????????????????????40結(jié)果??????????????????????????????44討論??????????????????????????????46結(jié)論??????????????????????????????48參考文獻????????????????????????????一49綜述??????????????????????????????52攻讀碩士學位期間發(fā)表學術(shù)論文????????????????????6
5、3致謝??????????????????????????????64論文獨創(chuàng)性聲明???????????????????????????65論文使用授權(quán)聲明??????????????????????????65論文審閱認定書???????????????????????????66徐州醫(yī)學院碩士學位論文縮略詞aCSFAUCBBBBTBC瑚xCMC-NaDMSOECFEDT八GEMIS1．p．i．1．腳PRTu2THUT姐x縮略詞表Abbreviation英文全稱ArtificialcerebrospinalfluidAreaundertheconcentrationcurveBl
6、oodbrainbarrierBloodtumotbarrierPeakconcentrationSodiumcarboxymethylcelluloseDimethylsulfoxideExtracellularfluidEthylenediaminetetraaceticacidGemcitabineInternalstandardIntroperitonealIntralesionalMeanResidenceTimePenetrationRatioEliminationhalflifeTetrahy’drouridinePeaktime中文全稱人工腦脊液藥時曲線下面積血腦屏障
7、血瘤屏障峰濃度羧甲基纖維素鈉鹽二甲基亞砜細胞外液乙二胺四乙酸吉西他濱內(nèi)標腹腔內(nèi)注射瘤腔內(nèi)注射滯留時間通透率消除半衰期四氫尿苷達峰時間德州醫(yī)學阮砸貞士掌位記-又吉西他濱在大鼠腦膠質(zhì)瘤模型中的藥動學研究及冰片對其藥動學的影響第一部分吉西他濱在大鼠腦膠質(zhì)瘤模型中的藥動學研究中文摘要目的考察不同給藥方式后，吉西他濱在腦膠質(zhì)瘤模型腫瘤區(qū)域及外周血的藥動學特征。方法將24只SPF級SD大鼠隨機分為2組，瘤腔給藥組及腹腔給藥組，各組大鼠每只腦內(nèi)接種2×105個9L腦膠質(zhì)
